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The FDA approved semaglutide (Wegovy) in 2021 for chronic weight management in adults with a BMI of 27 or higher and at least one weight-related health condition, or a BMI of 30 or higher regardless of comorbidities

Within the VEGF family, there are distinct isoforms binding to VEGF receptors (VEGFR1-3) and neuropilin coreceptors (Nrp-1, Nrp-2), including VEGF-A, VEGF-B, VEGF-C, VEGF-D, and Placental Growth Factor (PlGF)

The cGASSTING pathway in macrophages is activated by double-stranded DNA released from damaged tubular epithelial cells, which subsequently promotes inflammatory responses (Jiao et al., 2025)

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Step 5: Purification of compound of formula- 13 The crude compound of formula- 13 obtained in step 4 (12 gm) was dissolved in 50% methanol in water at 25-30C and sonicated

After farrowing, the number of litters were adjusted to 12 1 piglets per litter by cross-fostering in the same treatment and one piglet with body weight (BW) closed to average litter BW was selected to be slaughtered for jejunum collection within 24 h